Hypersensitivity pneumonitis: a clinical, radiological, and pathological correlation
Fecha
2023-01Autor
Resumen
Hypersensitivity pneumonitis (HP) is an immune-mediated interstitial lung disease affecting genetically susceptible individuals sensitized to various inhaled antigens. Its manifestations and clinical course are heterogeneous. Diagnostic criteria for HP include identifying the inciting antigen, characterization of imaging findings, lymphocytosis in bronchoalveolar lavage (BAL), and in some patients, histopathologic findings on lung biopsy. HP is classified into two phenotypes: nonfibrotic and fibrotic. On high-resolution computed tomography (HRCT), nonfibrotic HP presents parenchymal changes (ground-glass opacities and attenuation mosaic) and signs of airway disease (centrilobular nodules and air trapping). Fibrotic HP presents fibrosis (reticulation, traction bronchiectasis, and honeycombing) and signs of airway disease (a three-density pattern, mosaic attenuation, and centrilobular nodules). The association of parenchymal and airway changes on HRCT suggests a diagnosis of HP in patients with interstitial lung disease (ILD) regardless of their distribution and features.
Keywords
URI
http://repositorio.mederi.com.co/handle/123456789/733https://www.jmexfri.com/frame_esp.php?id=36
Colecciones
- Investigación clínica [389]