Ictericia Colestásica como manifestación paraneoplásica (Una rara variante del síndrome de Stauffer: A propósito de un reporte de caso y revisión de la literatura)

Abstract

Stauffer syndrome is a rare frequency, first described by the American gastroenterologist Maurice H. Stauffer as aparaneoplastic manifestation in a patient with renal cell carcinoma. Classically presents as cholestasis without jaundice not associated with an apparent cause or without underlying disease (1). However, an unusual variant of this syndrome has been described with cholestasis and jaundice.Cholestatic jaundice that is associated with malignancy is generally the result of obstruction of the bile ducts or liver metastases; however, cases of cholestasis not related to the bile duct have been described, but as a paraneoplastic manifestation of a malignant entity, described as Stauffer syndrome characterized by being a clinical entity that manifests itself through reversible intrahepatic cholestasis, classically described in patients with renal cell carcinoma andless frequently in other forms such as prostate, pancreatic, bronchogenic lung cancer (2). Unlike its classic form, a variant characterized by generalized jaundice has been described (3). The case of a patient who is admitted to the hospital in the context of a jaundice syndrome is described, ruling out possible biliary, infectious, autoimmune and infiltrative obstructive causes by liver biopsy. Prostate carcinoma was diagnosed, radical treatment was given, and finally presented rapid clinical improvement.