Latent rheumatic, thyroid and phospholipid autoimmunity in hospitalized patients with COVID-19
Fecha
2021-03Autor
Resumen
-
Abstract
Autoimmune responses mediated by autoantibodies have been observed in SARS-CoV-2 infection. Herein, weevaluate the presence of rheumatic, thyroid and phospholipid autoantibodies in sera samples from 120 adulthospitalized patients with COVID-19 in comparison to pre-pandemic samples from 100 healthy individuals. Inaddition, to estimate the frequency of these autoantibodies in COVID-19, a meta-analysis of selected articles wasconducted. Hospitalized patients with COVID-19 had latent autoimmunity characterized by a high frequency ofanti-thyroid peroxidase antibodies, rheumatoid factor (RF), anti-cyclic citrullinated peptide third generationantibodies, antinuclear antibodies (ANAs), IgM anti-β2-glycoprotein I (β2GP1) and IgM anti-cardiolipin anti-bodies. The meta-analysis confirmed our results, with RF and ANAs being the most common autoantibodies. Inaddition, cluster analysis revealed that those patients with high frequency of RF, IgM anti-β2GP1 antibodies andANAs had a longer hospital stay, required more vasopressors during hospitalization, and were more likely todevelop critical disease. These data suggest that latent autoimmunity influences the severity of COVID-19, andsupport further post-COVID studies in order to evaluate the development of overt autoimmunityAutoimmune responses mediated by autoantibodies have been observed in SARS-CoV-2 infection. Herein, weevaluate the presence of rheumatic, thyroid and phospholipid autoantibodies in sera samples from 120 adulthospitalized patients with COVID-19 in comparison to pre-pandemic samples from 100 healthy individuals. Inaddition, to estimate the frequency of these autoantibodies in COVID-19, a meta-analysis of selected articles wasconducted. Hospitalized patients with COVID-19 had latent autoimmunity characterized by a high frequency ofanti-thyroid peroxidase antibodies, rheumatoid factor (RF), anti-cyclic citrullinated peptide third generationantibodies, antinuclear antibodies (ANAs), IgM anti-β2-glycoprotein I (β2GP1) and IgM anti-cardiolipin anti-bodies. The meta-analysis confirmed our results, with RF and ANAs being the most common autoantibodies. Inaddition, cluster analysis revealed that those patients with high frequency of RF, IgM anti-β2GP1 antibodies andANAs had a longer hospital stay, required more vasopressors during hospitalization, and were more likely todevelop critical disease. These data suggest that latent autoimmunity influences the severity of COVID-19, andsupport further post-COVID studies in order to evaluate the development of overt autoimmunity
Palabras clave
COVID-19 ; SARS-CoV-2 ;
Keywords
URI
http://repositorio.mederi.com.co/handle/123456789/582https://www.sciencedirect.com/science/article/pii/S2589909021000113
Colecciones
- Investigación clínica [389]