Survival Outcomes of Hepatectomy in Gastric Cancer Liver Metastasis: A Systematic Review and Meta-Analysis

Conde-Monroy, Danny; Ibañez-Pinilla, Milciades; Sabogal-Olarte, Juan Carlos; Rey-Chaves, Carlos; Isaza-Restrepo, Andrés; Girón, Felipe; Vanegas, Marco; Ibañez-Villalba, Rafael; Mirow, Lutz; Siepmann, Timo

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dc.creator	Conde-Monroy, Danny
dc.creator	Ibañez-Pinilla, Milciades
dc.creator	Sabogal-Olarte, Juan Carlos
dc.creator	Rey-Chaves, Carlos
dc.creator	Isaza-Restrepo, Andrés
dc.creator	Girón, Felipe
dc.creator	Vanegas, Marco
dc.creator	Ibañez-Villalba, Rafael
dc.creator	Mirow, Lutz
dc.creator	Siepmann, Timo
dc.date.accessioned	2023-02-14T00:28:48Z
dc.date.available	2023-02-14T00:28:48Z
dc.date.created	2023-01
dc.identifier.issn	2077-0383	spa
dc.identifier.uri	http://repositorio.mederi.com.co/handle/123456789/743
dc.description	Gastric cancer liver metastasis (GCLM) is a contraindication for surgical treatment in current guidelines. However, the results of recent studies are questioning this paradigm. We assessed survival outcomes and their predictors following hepatectomy for GCLM in a systematic review of studies published from 2000 to 2022 according to PRISMA guidelines. We identified 42,160 references in four databases. Of these, 55 articles providing data from 1990 patients fulfilled our criteria and were included. We performed a meta-analysis using random-effects models to assess overall survival (OS) and disease-free survival (DFS) at one, three, and five years post-surgery. We studied the impact of potential prognostic factors on survival outcomes via meta-regression. One, three, and five years after surgery, OS was 69.79%, 34.79%, and 24.68%, whereas DFS was 41.39%, 23.23%, and 20.18%, respectively. Metachronous presentation, well-to-moderate differentiation, small hepatic tumoral size, early nodal stage, R0 resection, unilobar compromisation, and solitary lesions were associated with higher overall survival. Metachronous presentation, smaller primary tumoral size, and solitary metastasis were linked to longer DFS. The results of our meta-analysis suggest that hepatectomy leads to favorable survival outcomes in patients with GCLM and provides data that might help select patients who will benefit most from surgical treatment.	spa
dc.format.mimetype	application/pdf	spa
dc.relation.uri	https://doi.org/10.3390/jcm12020704	spa
dc.rights	Atribución-NoComercial-SinDerivadas 2.5 Colombia	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/2.5/co/	*
dc.title	Survival Outcomes of Hepatectomy in Gastric Cancer Liver Metastasis: A Systematic Review and Meta-Analysis	spa
dc.subject.keyword	gastric cancer	spa
dc.subject.keyword	hepatectomy	spa
dc.subject.keyword	meta-analysis	spa
dc.subject.keyword	mortality	spa
dc.subject.keyword	survival	spa
dc.rights.accessRights	openAccess	spa
dc.type.hasVersion	acceptedVersion	spa

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