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Variations in clinical course and surgical outcomes of acute appendicitis during COVID-19 Pandemic: A multicenter prospective cohort study

dc.creatorRey Chaves, Carlos Eduardo
dc.creatorGiron-Arango, Felipe
dc.creatorNuñez-Rocha, Ricardo
dc.creatorBenitez, Elkin
dc.creatorRuiz, Saralia
dc.creatorRodriguez, Lina
dc.creatorAyala, Daniela
dc.creatorVillamil, Carlos Jose
dc.creatorGalvis, Valentina
dc.creatorVanegas, Marcos
dc.creatorGomez, Monica
dc.creatorNassar, Ricardo
dc.creatorHernandez, Juan David
dc.creatorConde Monroy, Danny
dc.creatorGomez, Maria
dc.date.accessioned2022-12-19T20:53:13Z
dc.date.available2022-12-19T20:53:13Z
dc.date.created2022-11-08
dc.identifier.urihttp://repositorio.mederi.com.co/handle/123456789/725
dc.descriptionBackground COVID-19 pandemic has led to changes in the presentation and treatment of surgical pathologies. Therefore, we aim to describe the inuence of the COVID-19 pandemic on the clinical presentation and management of acute appendicitis and its surgical outcomes. Study design A multicenter cohort study with prospectively collected databases. Three high-volume centers were included and all patients over 18 years of age who underwent appendectomy for acute appendicitis were included. Multiple logistic regression and multinomial logistic regression were performed, and odds ratio, relative risk, and B-coecient were reported when appropriate, statistical signicance was reached with pvalues < 0.05. Results 1.468 patients were included (709 in the pre-pandemic group and 759 in the COVID-19 group). Female patients constituted 51.84%. Mean age was 38.13 ± 16.96 years. Mean Alvarado's score was 7.01 ± 1.59 points. Open surgical approach was preferred in 90.12%. Conversion rate of 1.29%. Mortality rate was 0.75%. There was an increase of perforated and localized peritonitis (p 0.01) in the COVID-19 group. Presence of any postoperative complication (p 0.00), requirement of right colectomy and ileostomy (p 0.00), and mortality (p 0.04) were higher in the COVID-19 group. Patients in the pre-pandemic group have a lesser risk of mortality (OR 0.14, P 0.02, 95% CI 0.02–0.81) and a lesser relative risk of having complicated appendicitis (RR 0.68, P 0.00, 95% CI 0.54–0.86). Conclusion Complicated appendicitis was an unexpected consequence of the COVID-19 pandemic, due to surgical consultation delay, increased rates of morbidity, associated procedures, and mortality, inuencing the clinical course and surgical outcomes of patients with acute appendicitis.spa
dc.format.mimetypeapplication/pdfspa
dc.relation.urihttps://doi.org/10.21203/rs.3.rs-2194510/v1spa
dc.rightsAtribución-NoComercial-SinDerivadas 2.5 Colombia*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/2.5/co/*
dc.titleVariations in clinical course and surgical outcomes of acute appendicitis during COVID-19 Pandemic: A multicenter prospective cohort studyspa
dc.subject.keywordAppendicitisspa
dc.subject.keywordCOVID-19spa
dc.subject.keywordMulticenter Studyspa
dc.subject.keywordOutcomesspa
dc.subject.keywordSARS-CoV-2spa
dc.subject.keywordSurgeryspa
dc.rights.accessRightsopenAccessspa
dc.type.hasVersionacceptedVersionspa


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