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Psychometric Validation of the M. D. Anderson Symptom Inventory–Head and Neck Module in the Spanish Language
Context
The assessment of cancer-related symptoms requires culturally adapted and psychometrically validated symptom assessment tools. The M. D. Anderson Symptom Inventory–Head and Neck Module (MDASI-HN) is a useful ...
Analyzing biological and molecular characteristics and genomic damage induced by exposure to asbestos
Asbestos is one of the most important occupational carcinogens. Currently, about
125 million people worldwide are exposed to asbestos in the workplace. According to global
estimates, at least 107,000 people die each year ...
New Insights into Clostridium difficile (CD) Infection in Latin America: Novel Description of Toxigenic Profiles of Diarrhea-Associated to CD in Bogotá, Colombia
Clostridium difficile (CD) produces antibiotic associated diarrhea and leads to a broad range of diseases. The source of CD infection (CDI) acquisition and toxigenic profile are factors determining the impact of CD. This ...
Mathematical-physical prediction of cardiac dynamics using the proportional entropy of dynamic systems
Heart dynamic characterized within the context of dynamical systems theory allows differentiating and
predicting normal cardiac states, different levels of disease, as well as evolution towards disease. The
purpose of ...
High frequency of toxigenic Clostridium difficile and Clostridium perfringens coinfection among diarrheic patients at health care facility-onset (HCFO) and community-onset (CO) centers in Bogotá, Colombia
Background:The aim of this study was to evaluate the frequency of toxigenic C. difficile and C. perfringens infections at health care facility‑onset (HCFO) and community‑onset (CO), in two health care centers (HCC) in ...
Creating and validating a warfarin pharmacogenetic dosing algorithm for Colombian patients
Purpose
Warfarin is an oral anticoagulant associated with adverse reaction to drugs due to wide inter- and intra-individual dosage variability. Warfarin dosage has been related to non-genetic and genetic factors. CYP2C9 ...
A Pharmacogenomic Dissection of a Rosuvastatin-Induced Rhabdomyolysis Case Evokes the Polygenic Nature of Adverse Drug Reactions
Rosuvastatin, is a widely-used statin for the treatment of hypercholesterolemia and the prevention of cardiovascular diseases. Although rosuvastatin is well tolerated, about 3/10.000 patients can suffer severe myopathy. ...
Identifying new potential genetic biomarkers for HELLP syndrome using massive parallel sequencing
Background
Preeclampsia (PE) is a frequently occurring multisystemic disease affecting ~5% of pregnancies. PE patients may develop HELLP syndrome (haemolysis, elevated liver enzymes, and low platelet), a mother and foetus ...
Robust, Comprehensive Molecular, and Phenotypical Characterisation of Atypical Candida albicans Clinical Isolates From Bogotá, Colombia
Candida albicans is commensal in human microbiota and is known to be the commonest opportunistic pathogen, having variable clinical outcomes that can lead to up to 60% mortality. Such wide clinical behaviour can be attributed ...
Possible Genetic Determinants of Response to Phenytoin in a Group of Colombian Patients With Epilepsy
Background: Epilepsy is a serious health problem worldwide. Despite the introduction of new antiepileptic drugs (AEDs) almost 30% of these patients have drug-resistant forms of the disease (DRE), with a significant increase ...